Post-Doctoral Researcher Position at the Biology of Spirochetes Unit, Department of Microbiology, Institut Pasteur in Paris
Paris
CDD
Temps-plein
Il y a 23 jours
Offer DescriptionLeptospirosis is a re-emerging neglected zoonosis as climate and demographic changes fuel ideal conditions, including rising inequality, for rat-borne transmission to humans. Despite these concerning projections, little is known about the ability of the etiologic agent to adapt to different hosts and cause disease. Leptospira remains a challenging genus on which to perform genetic studies and is characterized by a high proportion of proteins of unknown function not present in other pathogens. This is generally also true for other spirochetes which are an ancestral and unique group of bacteria including the agents of important infectious diseases including Lyme disease and syphilis. They, therefore, represent an alternative model for the general understanding of host adaptation and evolution of pathogens. We have established a fantastic consortium to decipher Leptospira virulence mechanisms that includes teams specialized in host-pathogen interactions (Jenifer Coburn, Medical College Wisconsin), host response (David Haake, UCLA) and clinical leptospirosis (Megan Reller, Duke university).Your Role:As a key player in this project, you'll work closely with other collaborative teams, bridging the gap between cell biology, genomics and pathogenesis. With your expertise in cell biology (cell culture of human primary cells), you will characterize the mechanisms of host-adaptation of pathogenic Leptospira.Qualification:An expertise in molecular biology, bioinformatics, imaging and/or infectious models will be appreciated.Starting Date & Duration:This position is opened starting mid 2024 for a total of 3 years.Location:The Institut Pasteur ( ) is a world-renowned center of excellence for its research in biology, infectious diseases and immunology. The Institut Pasteur is located in the center of Paris and offers outstanding research facilities, including state-of-the-art imaging and omics, providing cutting edge technologies. The also hosts the French National Reference Center for Leptospirosis and a WHO Collaborating Center for Reference and Research on Leptospirosis.References:Evolutionary insights into the emergence of virulent Leptospira spirochetes. Alexandre Giraud-Gatineau, Cecilia Nieves, Luke Harrison, Nadia Benaroudj, Frederic J. Veyrier, Mathieu Picardeau.Zavala-Alvarado C, G Huete S, Vincent AT, Sismeiro O, Legendre R, Varet H, Bussotti G, Lorioux C, Lechat P, Coppée JY, Veyrier FJ, Picardeau M, Benaroudj N. PLoS Pathog. 2021 Dec 2;17(12):e1009087. doi: 10.1371/journal.ppat.1009087. eCollection 2021 Dec.PMID: 34855911RequirementsResearch Field Biological sciences » Biology Education Level PhD or equivalentSkills/QualificationsAn expertise in molecular biology, bioinformatics, imaging and/or infectious models will be appreciated.Languages ENGLISH Level ExcellentResearch Field Biological sciences » OtherMedical sciences » OtherAdditional InformationSelection processSend your CV and a motivation letter with at least two references to:Work Location(s)Number of offers available 1 Company/Institute Institut Pasteur Country France GeofieldWhere to apply E-mailmpicard@pasteur.frContact State/ProvinceIle-de-France CityPARIS WebsiteStreet28 rue du Dr Roux Postal Code75015 E-Mailmpicard@pasteur.frSTATUS: EXPIRED