Associate Director Integrated Bioanalysis – Proteomics
AstraZeneca
- Gaithersburg, MD
- Permanent
- Full-time
- PhD in analytical chemistry, biochemistry , genomics molecular biology or related discipline with at least 7 years of post-PhD experience
- Proven experience as a Subject Matter Expert in an array of proteomics techniques including the development broad spectrum and targeted proteomics strategies.
- Experience in both hypothesis generation and targeted analyses approached to using proteomics to resolve to perform pathway analysis or biomarker strategies.
- Design, execute, and troubleshoot technical challenges as they arise to ensure data is generated in a fit-for-purpose manner.
- Able to evaluate and interpret complex data sets.
- You will also be called upon to contextualize and interprets data for use in key project decisions.
- Employ a metabolomic/proteomics discovery platform to enable discovery and validation of metabolomic/lipidomic/proteomics biomarkers.
- Experience using a broad array of proteomics platforms including but not limited to high resolution mass spectrometry (HRMS, ToF or Orbitrap), QqQ instruments and ligand binding based technology platforms.
- Hands-on experience with chromatographic separation, characterization, and quantification of various analytes by LCMS or protein array platforms.
- Excellent organizational, documentation and technical writing skills
- Proficiency with mass spectrometry and other protein array software, data analysis software (Spotfire, MATLAB, R, JMP, etc.) word processing, and graphical computer programs
- Contribute to project technical teams to ensure effective communication and interpretation of data.
- Collaborate effectively to ensure productive interactions with all stakeholder groups.
- Foster advance technical applications to ensure data quality.
- Demonstrate strong accountability, organizational and interpersonal skills, and apply scientific and technical experience.
- Ensure high-quality, timely documentation in electronic laboratory notebooks and technical reports which support regulatory filings.
- Present data/ strategy to scientists and management in internally.
- Other duties as assigned. Interpretation of integrated and complicated datasets
- Ability to handle multiple projects and / or tasks concurrently in a fast-paced environment
- Ability to develop, coach and mentor
- Background in pharmaceutical clinical trial research
- Proven publication and presentation record
- Exceptional verbal and written communication skills
- Experience with a broard array of multi-omic techniques including but not limited to RNA seq, cell- painting or genomics applications.
- Experience across a range of technology platforms including but not limited to LBA, Wester-blot, and PCR.
- Experienced in regulated bioanalysis for a range of drug modalities.