Principal/Senior Scientist, Discovery & Translation

• Lead and contribute to the design, execution, and interpretation of experiments to validate novel drug targets.
• Oversee design and screening of new AAV constructs for discovery
• Develop and optimize assays and screening strategies to characterize lead gene therapy candidates.
• Collaborate with cross-functional teams to advance drug discovery and development projects.
• Analyze and interpret data from in vitro and in vivo pharmacology &safety studies.
• Research latest scientific trends and technological advances in gene therapy.
• Design and oversee preclinical studies to evaluate the efficacy and safety of candidate therapeutics.
• Contribute to the preparation of regulatory documents, including IND submissions.
• Mentor and supervise junior scientists in a cross-functional setting.
• Present research findings at internal meetings, scientific conferences, and in peer-reviewed publications.

• Ph.D. in Molecular Biology, Genetics, Bioengineering, or a related field.
• 5+ years of post-Ph.D. experience in a biotech/pharma setting, with a focus on gene therapy research.
• Drug Discovery for gene therapy or nucleic acid medicines
• Familiar with AAV gene therapy design and development
• CRO management for conducting in vivo research studies
• Designing in vivo gene therapy studies and dosing
• Experience in biodistribution studies and pharmacology related to gene therapy applications.
• Gene therapy assay development
• Designing IND-enabling studies is a plus.
• Deep understanding of molecular biology techniques (RNA/DNA isolation, ddPCR, RNAscope, western blot)
• AAV vector design, titering, dosing
• Expertise in in vivo models for biodistribution and pharmacology studies.
• Strong analytical skills and proficiency in statistical data analysis.
• Excellent communication and project management abilities.
• Graphpad, excel etc.

Lexeo Therapeutics