Senior Scientist, Translational Cytomics, Hematology R&D
AstraZeneca
- Waltham, MA
- Permanent
- Full-time
- Preparing, and executing procedures of single-cell RNA sequencing using different types of specimens.
- Optimization of methods for single cell/nuclei sequencing from fresh and archival clinical samples and solve problems during the process.
- Transition of new technologies from proof-of-concept to standardized workflows.
- Delivery of reliable and high-quality data and metadata to computational analysis.
- Assist with bulk NGS experiments as required.
- Synergize with Translational Research Scientists, Translational Medicine Leads and computational biologists.
- This is a laboratory-based position.
- Ph.D. in biological sciences with NGS laboratory experience, or M.S. in biological sciences with 2+ years NGS laboratory experience.
- Hands-on experience in single cell RNA sequencing techniques required, with exposure to spatial transcriptomics approaches preferred: specimen handling, quality control assessments, droplet-based cell processing, library construction and sequencing.
- Familiarity with theory and operations of platforms such as Chromium with preference to additional familiarity in theory and operations of Visium, Xenium and similar platforms.
- Deep understanding in immunology, cancer, genomics, and RNA biology.
- Solid track record of performance, including successful completions of projects within a given timeframe and budget.
- Outstanding ability to work independently and with a team- including problem solving, brainstorming, integrating data and helping other team members.
- Excellent organizational and documentation skills.
- Excellent data presentation skills.
- Innovative approach and enthusiasm to explore new technologies.
- Mastery of R-based or Python-based analysis of single cell NGS and bulk NGS data.