Neurodegenerative diseases are one of the largest medical challenges of our time. Denali Therapeutics is a biotechnology company dedicated to developing breakthrough therapies for neurodegenerative diseases through our deep commitment to degeneration biology and principles of translational medicine. Denali is founded on the collaboration of leading scientists, industry experts, and investors who share the vision that scientific discovery energetically applied to translational medicine is the key to delivering effective therapies to patients.We invite you to consider an opportunity with Denali to help achieve our goal of delivering meaningful therapeutics to patients.The OpportunityWe are seeking a talented and experienced scientist to develop, optimize, and establish state-of-the-art potency assays for our diverse pipeline of large molecule biotherapeutics. The ideal candidate should have hands-on experience in ligand-based and cell-based bioassays to characterize activity and potency of a variety of modalities including antibodies and Fc-fusion proteins as well as potentially oligonucleotide-conjugates and virus-based gene therapies. The candidate will join a broader process development group with opportunities to closely collaborate on all aspects of analytical, formulation, and process development.Key ResponsibilitiesIndependently design and perform experiments with a focus on binding, enzymatic activity, and cell-based bioassays.Developing, optimizing, and qualifying bioassays for product release and stability testing as well as to supporting cell-line, bioprocess, and formulation development activities.Serve as subject matter expert (SME) for potency assays, promoting innovation and exploring novel techniques or technology and approaches for developing, optimizing, qualifying, and troubleshooting of complex assays.Responsible for leading and supporting testing for extended characterization studies of early and late-stage projects.Maintaining complete and accurate records and contribute to continuing process improvement.Representing Bioassay team cross-functionally and continuously drive Bioassay method development through internal and external collaborations.Presenting experimental results in team meetings.Detailed recording and analysis of experiments in an electronic laboratory notebook (ELN)Coordinating parallel tasks across multiple projects and prioritizing deliverables to meet departmental and organizational goals.Salary Range: $121,000.00 - $153,000.00. Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. Denali offers a competitive total rewards package, which includes a 401k, healthcare coverage, ESPP and a broad range of other benefits. Learn more at https://www.denalitherapeutics.com/careersThis compensation and benefits information is based on Denali’s good faith estimate as of the date of publication and may be modified in the future.Denali is committed to its core company value of unity by creating a diverse and inclusive environment. We are proud to be an equal opportunity employer and do not discriminate against any employee or applicant for employment because of race, color, sex, age, national origin, religion, sexual orientation, gender identity and/or expression, status as a veteran, basis of disability, or any other federal, state, or local protected class.Applicant Privacy Policy