Principal Scientist or Assoc. Dir. of T cell in vivo Pharmacology
Adaptimmune
- Cambridge, MA
- Permanent
- Full-time
- Establish and develop syngeneic and/or humanized mouse models to test Pipeline and Preclinical candidates, collaborating with UK and US stakeholders to select appropriate models.
- Lead and conduct in vivo and ex vivo pharmacology studies supporting candidate selection, mechanism-of-action, and IND-enabling studies for Pipeline and Preclinical Research.
- Develop, evaluate and validate in vivo tumor models, PK/PD methods, and ex vivo immunoprofiling studies.
- Offer expert guidance and hands-on support to in vitro immunology studies.
- Collaborate cross-functionally as in vivo lead representative on preclinical project teams.
- Author study protocols and reports, prepare documents (e.g., IND reports) oversee data analysis, and assimilate data packages for clear communication to internal stakeholders or external presentation/publication.
- Manage Vivarium operations, ensuring compliance with IACUC protocols and adherence to animal use and care guidelines, policies, and regulations.
- PhD in a biology discipline with 5+ years post-PhD experience (2+ years in industry) with in vivo studies of cell therapies and/or cancer immunotherapies (e.g, CAR-T).
- Experienced in the development, technical execution, and validation of xenogeneic and syngeneic and/or humanized mouse tumor (solid and hematologic) model studies.
- Extensive experience in preclinical in vivo evaluation of T cell therapies with coupled expertise in ex vivo T-cell pharmacokinetic and pharmacodynamic readouts such as T-cell persistence, immunophenotype, biodistribution (by flow cytometry and IHC), cytokine release
- Firsthand expertise in ex vivo immunoprofiling using ELISA and flow cytometry, with high favourability toward experience with adoptive T cells.
- Highly practiced in mouse handling, including drug administration (e.g., by IP, IV, SQ) blood collection, surgical dissection, and euthanasia in accordance with animal care guidelines.
- Demonstrated commitment to quality, excellent attention to detail, experience managing in vivo electronic databases and records; experienced user of electronic laboratory notebooks
- Demonstrated track record of working collaboratively and overcoming challenges.
- Subject expertise in in vivo evaluation of T cell therapeutics (CAR-T, TCR-T, TRuC, or BiTEs)
- Strong understanding of T cell biology, tumor immune microenvironment.
- Experience in executing and authoring IND-enabling preclinical in vivo studies and reports.
- Experience with managing CROs