Scientific Lead, Analytical and Mass-Spectrometry Large Molecule Discovery
Eli Lilly
- San Francisco, CA
- $104,250-195,800 per year
- Permanent
- Full-time
- Perform sample prep on and support the overall development, optimization, and execution of analytical assays for protein characterization and bioanalysis.
- Support BioAnalysis sample preparation from complex matrixes (plasma/tissue) for mass spectrometry-based ligand binding assays.
- Flexibility in supporting and participating in new projects and contributing to changing deadlines.
- Prepare and analyze antibody/ADC samples for routine testing on analytical instruments such as RP-HPLC, SEC, LCMS (High Resolution and QQQ)
- Advance the LCMS and analytical capabilities of lab to gain insights into ADC designs and mechanisms of action
- Collaborate with the team to meet timelines and deliverables.
- Perform general lab maintenance and instrument calibrations.
- Maintain a high level of productivity in a laboratory setting.
- A BSc and
5 years of directly relevant experience with LC-MS in a drug development setting, or a PhD in a relevant scientific discipline (level commensurate with education and experience) * Prior hands-on experience generating and interpreting LC-MS data to support large molecule drug programs is essential.
- High level of proficiency of Excel or prism, is required
- Excellent communication and interpersonal skills with strong organizational abilities
- Experience troubleshooting, maintaining of mass spectrometers and LC
- Proven track record in conceiving and implementing creative LCMS and other analytical solutions in the lab to advance the understanding of drug mechanism of action or developability
- Extensive hands on experience operating and maintaining Sciex 7500 Qtrap, Orbitrap, or other MS instruments.
- Previous work with antibodies, ADCs and other biotherapeutics and/or small molecule drugs
- Additional hands-on experience using analytical characterization such as SEC/HIC, U/HPLC, cIEF, CE, LC-MS, and cLIF is a plus
- Prior experience working with high capacity/throughput analysis of plasma and other samples is a plus
- Experience with high throughput plate-based assays (Working with automation is a plus)
- Experience developing and validating assays using LCMS targeted MS or proteomics techniques
- Experience analyzing and interpreting and reporting analytical data, along with sharing and presenting data to collaborators.
- Experience with and/or a deep understanding of PK and BioAnalysis of small molecule drugs or ADC biologic drugs
- Experience with R for data visualization is a plus.
- Demonstrated can-do attitude. Looking for someone that brings innovative ideas to challenging projects in a fast-paced, collaborative, and cross-functional organization