Associate Principal Scientist Metabolism In Vivo Team
AstraZeneca
- Gaithersburg, MD
- Permanent
- Full-time
- You will be an expert in your area and play an active role in implementing and performing scientific research and development strategy within the metabolism department, enabling the prosecution of a rapidly growing portfolio of drug projects across multiple modalities.
- Be a "hands-on" expert in developing new in vivo models and methodologies with an enthusiasm for laboratory work and scientific curiosity. Play a leading role in assay development and optimization of screening cascades in relevant in vivo disease models, being responsible for design, execution, analysis and communication of in vivo studies.
- Act as lead biologist and project leader for drug discovery projects.
- Act as a champion for novel approaches for drug discovery in metabolic disease area, promoting scientific debate within CVRM Research and playing a leading role in the selection and validation of new targets.
- Raise the scientific profile of CVRM both within AstraZeneca and externally through publications and presentations, as well as initiating or participating in external collaborations.
- PhD in life sciences with relevant postdoctoral experience.
- 5+ years industry experience with strong background in metabolic disease research areas such as diabetes, obesity, dyslipidemia and/or MASH.
- Proven expertise in in vivo pharmacology and physiology and hands-on skills to develop models supporting AstraZeneca’s discovery programs with expertise in surgical procedures; as well as drug metabolism and pharmacokinetics.
- Strong interest in problem solving through design and execution of complex in vivo mechanistic studies and robust expertise in data analysis, interpretation and data quality control.
- Evidence of scientific leadership recognised by publication record in leading peer reviewed journals, with enthusiasm to maintain a high external scientific profile through publication and conference presentations.
- Excellent organisational, time management, communication and interpersonal skills.
- Experience working within drug discovery projects in pharmaceutical or biotech environment with proven expertise in leading drug discovery projects
- Significant experience of numerous in vitro and ex vivo technologies for assessing signaling endpoints for multiple target classes (qPCR, Western Blots, ELISA).
- Experience of writing ethical applications and managing IACUC protocols relevant to in vivo models/studies
- Strong ability in leading several simultaneous projects/tasks