Post-doctoral fellow (M/F) innovative therapies
- Lyon
- CDD
- Temps-plein
a new murine animal model for a rare neurodegenerative disease called Giant Axon Neuropathy (GAN).
The recruited agent will evaluate the biodistribution/toxicity/efficacy of therapeutic vectors (gene therapy and pharmacology) on the NAG mouse model, through behavioral and histopathological studies.
12-month contract with possibility of renewal.Translated with DeepL.com (free version)Activity 1: study of biodistribution & toxicity of therapeutic vectors: q-PCR
Activity 2: blood and tissue sampling (perfusion & dissection)
Activity 3: study of vector efficacy: behavioral & histopathological analysis
Activity 4: gigaxonin expression analysis: q-PCR and western blot
Activity 5: support for mouse cohort managementThe post-doc recruited will work in the Bomont team (10 people) at INMG-PGNM in Lyon. He/she will be under the supervision of Dr Pascale Bomont and will work with 2 IEs on a project to develop an innovative therapy in the mouse model for a rare disease.
Collaboration with technical platforms (mouse animal facility and imaging) and with a team in Paris (ICM).RequirementsResearch Field Neurosciences Education Level PhD or equivalentResearch Field Biological sciences Education Level PhD or equivalentLanguages FRENCH Level BasicResearch Field Neurosciences Years of Research Experience NoneResearch Field Biological sciences Years of Research Experience NoneAdditional InformationEligibility criteriaSkills/knowledge: animal experimentation (experimenter or designer diploma essential), knowledge of neurobiology and molecular biology (qPCR techniques, western-blot) would be a plus.
Know-how: mouse handling (mainly behavior, but also histology, immuno(histo)chemistry)
People skills: interacting within a group
Managerial skills: ability to evaluate results and sense of criticism/discussion, presentation of results to the team (labmeetings and electronic lab notebook)Website for additional job detailsWork Location(s)Number of offers available 1 Company/Institute Pathophysiologie et génétique du neurone et du muscle Country France City LYON 08 GeofieldWhere to apply WebsiteContact CityLYON 08STATUS: EXPIRED
EURAXESS