Antibody Discovery Scientist
AbbVie
- Oxford
- £66,000-127,500 per year
- Permanent
- Full-time
- A new role due to expansion.
- Based at the vibrant research community of Oxford.
- Comprehensive benefits package.
- Amazing career opportunities in a growing division with exceptional training.
- Contribute to integrating our diverse discovery technologies into one unified discovery platform.
- Work alongside data scientists to develop systems for tracking, curating and exploit data from discovery campaigns including antibody sequence data.
- Perform critical laboratory experiments and analysis to develop and extend existing technologies.
- Work to characterize the strengths and weaknesses of novel formats for integral membrane proteins such and virus-like particles and nanodiscs.
- Mentor junior scientists from the bench side in new and novel biochemical techniques and methodologies.
- Develop their skill set to become a go-to expert for antibody discovery technology.
- Keeping up-to-date with developments in the literature in relation to antibody discovery technologies.
- Contribute ideas and suggestions to all DJS programs.
- Develop and refine DJS internal laboratory capabilities.
- Gather, analyse and present data from a variety of sources to the wider team and organization.
- Critically and impartially review self and peer generated laboratory data to create tangible actions
- Maintenance of laboratory experimental records.
- Bringing energy, enthusiasm and positivity to the company
- A PhD or equivalent level of experience of working in a research laboratory
- Enthusiasm and commitment to drug development research.
- Proven experience of antibody drug discovery.
- Proven expertise and experience in:
- Antibody isolation using phage display or any single B-cell technology
- Isolating and enriching antibody-secreting cells or memory B cells
- Flow cytometry
- Molecular biology of antibodies: amplifying VH and VL domains, basic VDJ genetics, etc
- Range of antibody cloning, expression and purification techniques
- Construction and curation of Ig gene sequence library databases using tools such as PipeBio, Genedata and Geneious Biologics
- Desirable skills:
- Experience working with 10X genomics or similar sequencing approaches for variable region sequencing
- Delivery of therapeutic format antibodies with drug like properties
- Experience with high-throughput antibody screening assays
- Experience with therapeutic antibody optimization: humanization; affinity optimization and liability removal
- Experience with protein biochemistry techniques e.g. FPLC
- Experience working with contract research organisations
- Experience with antibody binding techniques; ELISA, FACS, SPR etc.
- Experience working with experimental rodents and isolating cells from them
- Evidence of excellent organizational and interpersonal skills including
- Work both independently and as part of a team
- Ability to work efficiently with strong attention to detail
- Ability to build effective working relationships including with teams located at different geographical locations
- Laboratory method development
- Ability to work flexible hours when required
- Proven written and oral communicative ability
- Problem-solving skills
- Strong IT skills
- Flexible and adaptable with an all-inclusive goal-orientated mindset