Postdoctoral position in molecular modeling for the search for a treatment against a rare neurological disease (M/F)

  • Paris
  • CDD
  • Temps-plein
  • Il y a 14 jours
Offer DescriptionThe laboratory is exploring pharmacological approaches to treat a rare disease severely affecting neurological development of children. Salla disease is caused by a mutation on a protein, sialin, leading to defects in function and cell localization. The research project aims to develop a therapeutic solution to Salla disease with an innovative approach using molecular modeling. The structural information on the protein deficient in Salla disease makes it possible to propose this approach, which could lead to the development of a compound capable of compensating for the defect.
  • Conduct research in Molecular Dynamics Simulation with a focus on explicit membrane systems and constant pH simulations.
  • Implement and utilize Python codes for MD analysis, virtual screening, pharmacophore identification, and other related tasks.
  • Develop and apply Deep Learning tools for protein modeling, small molecule docking, and structure prediction.
  • Collaborate with interdisciplinary teams to advance research goals and contribute to scientific publications. The recruited postdoc will interact with an international research consortium, the FSASD consortium.
  • Present research findings at conferences and seminars.
The research will be carried out within the Membrane Dynamics team of SPPIN, UMR 8003RequirementsResearch Field Chemistry Education Level PhD or equivalentResearch Field Biological sciences Education Level PhD or equivalentResearch Field Pharmacological sciences Education Level PhD or equivalentLanguages FRENCH Level BasicResearch Field Chemistry Years of Research Experience 1 - 4Research Field Biological sciences Years of Research Experience 1 - 4Research Field Pharmacological sciences Years of Research Experience 1 - 4Additional InformationEligibility criteria
  • PhD in Computational Chemistry, Biophysics, Bioinformatics, or a related field.
  • Strong expertise in Molecular Dynamics Simulation techniques.
  • Proficiency in programming languages such as Python, with experience in developing codes for MD analysis.
  • Knowledge of Deep Learning frameworks and their applications in protein modeling and small molecule docking.
  • Excellent communication and collaboration skills.
  • Ability to work independently and as part of a team.
Website for additional job detailsWork Location(s)Number of offers available 1 Company/Institute Institut des Neurosciences Paris Saint-Pères Country France City PARIS 06 GeofieldWhere to apply WebsiteContact CityPARIS 06STATUS: EXPIRED

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