Postdoc Position
Université de Lausanne
- Lausanne
- Unbefristet
- Vollzeit
We are looking for a highly motivated postdoctoral researcher to study the role of TDP-43 in the control of microglial function.Microglia, the innate immune cells of the central nervous system, play important functions in the healthy as well as in the diseased brain. Several genes associated with neurodegeneration are highly expressed in microglia, and recent evidence suggests that these cells can critically influence the onset and course of brain diseases. However, the underlying cellular mechanisms are not entirely clear. In this project, we will investigate the role of the DNA-RNA binding protein TDP-43, as a modulator of different microglial functions. In particular, we will focus on the effects on phagocytic capacity and lipid metabolismJob informationExpected start date in position : 01.09.2024Contract length : 1 year with possibility of renewalActivity rate : 100%Workplace : Lausanne, Rue du Bugnon 7Your responsibilitiesThe project aims at investigating how the loss of function of TDP-43, selectively in microglia, affects lipid metabolism and myelination in pathological models (demylination induced by LPC). We will combine in vivo (TDP-43 microglial cKO mice) and ex vivo/in vitro models (organotypic slices and primary microglia cultures) with biochemical and histological approaches, confocal imaging, lipidomics and sc-RNA sequencing.Your qualifications·Full habilitation to work with animals is a must.·Expertise in microglia biology and lipid metabolism is highly appreciated.·Candidates are required to be fluent in written and spoken English.·The ideal candidate should have a strong background in neurobiology, be highly motivated, and able to work independently.What the position offers youThe University of Lausanne is a higher teaching and research institution composed of seven faculties where approximately 15,000 students and nearly 5,000 collaborators, professors, and researchers work and study. Ideally situated along the lake of Geneva, near Lausanne's city center, its campus brings together over 120 nationalities.Contact for further informationProf. Paolicellirosachiara.paolicelli@unil.chYour applicationDeadline : 30.06.2024Please, send your full application in Word or PDF.
Only applications through this website will be taken into account.For further details about the project and application, please contact: rosachiara.paolicelli@unil.chWe thank you for your understanding.Additional informationUNIL is committed to equal opportunities and diversity.UNIL supports early career researchers.