Scientist 2, Computational Chemistry
Eikon Therapeutics
- Hayward, CA
- $130,000-142,500 per year
- Permanent
- Full-time
- Provide computational chemistry program support across our drug discovery pipeline spanning screening library selection, hit identification/calling, hit to lead, and lead optimization
- Design and optimize drug candidates using advanced computational techniques including generation of testable hypotheses from structure-based and ligand-based modeling approaches
- Influence drug discovery project direction by independently conducting modern computational experiments
- Routinely employ expert knowledge and analysis of SAR, physiochemical and ADMET properties
- Apply machine learning and data analytics techniques to enhance computational chemistry workflows and accelerate the drug discovery process
- Collaborate closely with our data science team to integrate cutting edge AI/ML tools into our chemistry and drug discovery processes
- Postdoc fellowship or Ph.D. plus 2 years of relevant experience; or Master's plus 12 years of relevant experience; or Bachelor's plus 14 years of relevant experience
- Expertise with physics-based methods, molecular dynamics, conformational analysis, free energy perturbation, and quantum mechanics
- Proficiency in computational chemistry software, such as Schrödinger Suite, Rosetta, AlphaFold, Gromacs, or similar tools
- Experience with ligand-based design approaches, QSAR, QSPR, multiparameter optimization to rationalize SAR and design novel molecules
- Experience with cheminformatics data analysis, data mining and machine learning models to solve drug discovery problems
- Experience in screening library design, hit calling, and diversity analysis is preferred
- A track record of publications, patents and/or conference presentations in computational chemistry and/or drug discovery
- Familiarity in scientific programming (e.g. python, KNIME) and data analytics (Spotfire, DataWarrior, Pandas)
- Excellent problem-solving abilities and the ability to work in a fast-paced, dynamic research environment
- Strong communication skills with the ability to convey complex scientific concepts to both technical and non-technical stakeholders
- 401k plan with company matching
- Medical (premiums covered by Eikon at 95%), dental and vision insurance (premiums covered by Eikon at 100%)
- Mental health and wellness benefits
- Weeklong summer and winter holiday shutdowns
- Generous paid time off and holiday policies
- Life/AD&D Insurance (premiums covered by Eikon at 100%) and optional supplemental employee-paid life/AD&D policies
- Enhanced parental leave benefit
- Daily subsidized lunch program when on-site